2024/3/18 -In sum, we conclude that HTRA1 can remodel α-syn PFFs, decreasing their amyloid content, disrupting their morphology, and decreasing their seeding capacity.
2024/3/31 -HtrA1 may function as a tumor suppressor by controlling the epithelial-to-mesenchymal transition, and may function in chemotherapeutic responsiveness by ...
2024/3/18 -Finally, HTRA1 detoxifies α-syn fibrils and prevents formation of hyperphosphorylated α-syn accumulations in primary neurons. Our findings suggest that HTRA1 ...
2024/4/3 -Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This ...
2024/3/22 -Herein, we discovered that the HtrA serine peptidase 1 (HTRA1) level was considerably increased in DCM, and it was strongly associated with myocardial fibrosis.
2024/4/1 -歩行のふらつき、無気力やいらいら感、注意力や記憶力の低下などの神経障害による症状と、頭髪の薄さ、腰痛といった神経以外の障害による症状がおこる病気です。この遺伝子 ...
4日前 -Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease. Rainer Malik, ...
2024/4/18 -HTRA1 genes are associated with cerebral small vessel disease, age-related macular degeneration (AMD), multisite tumors, arthritis, pre-eclampsia and other ...
2024/3/13 -Heterozygous HTRA1-related cerebral small vessel disease, as its name suggests, is caused by a monoallelic mutation in HTRA1, the same gene implicated in ...
2024/4/5 -HtrA1 activates Erk (extracellular signal-regulated kinase) and expression of the transcription factor Brachyury in the posterior mesoderm, whereas SerpinE2 ...