2024/3/18 -In sum, we conclude that HTRA1 can remodel α-syn PFFs, decreasing their amyloid content, disrupting their morphology, and decreasing their seeding capacity.
2024/5/20 -Genetic variants in HTRA1 are associated with stroke risk. However, the mechanisms mediating this remain largely unknown, as does the full spectrum of ...
2024/4/18 -HTRA1 encodes a serine protease, a secreted protein that is widely expressed in the vasculature. HTRA1 regulates a wide range of physiological processes through ...
2024/8/6 -HTRA1 (HtrA Serine Peptidase 1) is a Protein Coding gene. Diseases associated with HTRA1 include Cerebral Arteriopathy, Autosomal Recessive, With Subcortical ...
2024/8/19 -HtrA1 is differentially expressed in adult mouse forebrain astrocytes and regulates astrocytic development and injury response. Inhibition of HTRA1 in the tumor ...
2024/4/1 -HTRA1（High Temperature Requirement Serine Peptidase A1）という遺伝子の変異によっておこることがわかっています。この遺伝子は、タンパクを分解する働きがあります。
2024/3/22 -Herein, we identified HTRA1 as a newly discovered cargo receptor responsible for the ER-to-Golgi transport of procollagen. HTRA1 plays a dual role by recruiting ...
2024/8/12 -Our data suggest that HtrA1 is directly involved in the β-amyloid pathway as it degrades various fragments of amyloid precursor protein while an HtrA1 inhibitor ...
2024/4/22 -The HtrA1 protein exists primarily as a trimer and is likely to be too large (approximately 150 kDa) to diffuse across BM, especially as the permeability of the ...
2024/4/18 -Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration.