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Introduction & Tool 1 to Induce Lasting Dopamine
Sponsors: Roka, InsideTracker, Headspace
What Dopamine (Really) Does
Two Main Neural Circuits for Dopamine
Fast and Slow Effects of Dopamine
Dopamine Neurons Co-Release Glutamate
Parkinson’s & Drugs That Kill Dopamine Neurons. My Dopamine Experience
Tool 3 Controlling Dopamine Peaks & Baselines
Tool 4 Caffeine Increases Dopamine Receptors
Pursuit, Excitement & Your “Dopamine Setpoint”
Addiction, Dopamine Depletion, & Replenishing Dopamine
Tool 5 Ensure Your Best (Healthy) Dopamine Release
Stimulants & Spiking Dopamine: Counterproductive for Work, Exercise & Attention
Caffeine & Neurotoxicity of MDMA
Amphetamine, Cocaine & Detrimental Rewiring of Dopamine Circuits
Tool 6 Stimulating Long-Lasting Increases in Baseline Dopamine
Tool 7 Tuning Your Dopamine for Ongoing Motivation
Validation of Your Pre-Existing Beliefs Increases Dopamine
Tool 9 Quitting Sugar & Highly Palatable Foods: 48 Hours
Wellbutrin & Depression & Anxiety
Tool 10 Mucuna Pruriens, Prolactin, Sperm, Crash Warning
Tool 12 Avoiding Melatonin Supplementation, & Avoiding Light 10pm-4am
Tool 13 Phenylethylamine (with Alpha-GPC) For Dopamine Focus/Energy
Social Connections, Oxytocin & Dopamine Release
Zero-Cost & Other Ways To Support Podcast & Research
Dopamine
Sponsors: Helix Sleep, WHOOP, ROKA, Momentous
Dopamine Brain Circuits
Goals & Addiction
Dopamine Dynamics, “Wave Pool” analogy
Craving, Motivation, Pursuit & Reward Prediction Error
Sponsor: AG1 (Athletic Greens)
Feedback Cues & Reward Contingent Learning, “Scoreboard”
Addiction; Pleasure & Pain Imbalance
Dopamine Release & Addictive Substances/Behaviors
Addiction Recovery, Binding Behaviors
Tools: Maintain Baseline Dopamine Levels
Sponsor: InsideTracker
Tool: Deliberate Cold Exposure & Dopamine
Prescriptions & Supplementation: L-Tyrosine, Mucuna Pruriens
Dopamine Trough Recovery, Postpartum Depression
Dopamine Dynamics, “Dopamine Stacking”; Intrinsic Motivation
Making Effort the Reward, Growth Mindset
Tool: Overcome Procrastination
Tool: Meditation & Procrastination
Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media
Introduction
What happens when you block dopamine
Which behaviors release dopamine?
Example of homeostasis
Does you develop dopamine tolerance?
Why does it work?
Let your dopamine receptors recover from the unnaturally high dopamine that's been flooding your brain
Using high dopamine activity as a reward for completing difficult work
What is my guilty pleasure?
Final thoughts
Intro
How dopamine plays a role in habit formation
Synapses connecting striatal subregions
Dopamine signaling promotes compulsive behavior in animal models
How to manipulate dopamine release in the dorsal medial striatum
Role of dopamine in addiction and neuropsychiatric disorders
Maternal care allocation
Connection between dopamine and compulsive reward seeking
Differences in how the dopamine system functions when stress hormones are elevated
Closing thoughts