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Growing up in Brooklyn
Hampshire College Summer Studies in Mathematics
Serving on the Priorities Committee at Harvard
Mapping diseases relative to genetic markers
What is a gene and how does it relate to DNA?
Challenges
What's happened in the last decade?
The power of collaboration
Scientists have a responsibility to nurture the scientific process
Conclusion
James R. Killian,Jr. Faculty Achievement Award Lecture SECRETS of the HUMAN GENOME
Killian Lecture February 14, 2017
Mapping Disease Genes: Principles (1980-1990)
Mapping the Human Genome (1990-2003)
Mapping Disease Genes (2000-2006)
Mapping the Human Genome (2000-2006)
Mapping Disease Genes (2007-present)
Therapeutic hypothesis: Modulate synaptic pruning
Mobilizing the troops and testing everyone
What did we do differently?
Clear targets, regular check-ins to make decisions and solve problems
Achieving Under-24 Hour Turnaround Time
Manufacturing principles guide our work
Minimizing Turnaround Time
College and University Testing
Growing interest in the model
Even with vaccine on horizon, there is a need for increased testing
Acknowledgements
The relationship between the Whitehead Institute and MIT
Genome Center production floor
Accuracy of the sequence
Signal elements
Regulating protein translation
What makes vertebrate genes unique?
Applications of the Genome Project
The Human Genome Project and cancer studies
Future priorities for other species
Is the human genome a comprehensive description of life?
Closing remarks
Intellectual change: Completeness
Most Conserved Non-Coding Elements
Three-dimensional architecture of the genome
Histone modifications
Do these chromatin domains encode functional non-coding RNAs?
What do non-coding RNAs do?
Localization of linked RNAs
Moving a transgene to a different part of the chromosome
RNA Story
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