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Agenda
Chinook's Commitment to Kidney Drug Development
IgA Nephropathy (TGAN)
Atrasentan Blocks Central Drivers of IgAN Pathogenesis
Atrasentan Thoroughly Evaluated in Diabetic Kidney Disease (DKD) including Phase 3 SONAR Study
ALIGN Study Design
ALIGN (Phase 3) Study Design
ALIGN Study Overview
AFFINITY (Phase 2) Study Design
Serum Immunoglobulin Profiles
Causes of glomerular injury
Pathogenesis
Anti-GBM antibodies
Trapping of circulating immune complexes
Location of trapping of ICs
Cell mediated glomerulonephritis
Non-immune mediated causes
Mechanism of glomerular injury in immune complex mediated glomerulonephritis
Progression of glomerulonephritis
Conclusion