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What is HER2-positive Breast Cancer?
What is HER2?
How do you know if you are HER2 positive?
What is Herceptin?
Why consider chemotherapy before surgery?
What are the benefits of neoadjuvant chemotherapy?
What are the benefits of chemotherapy for HER2 positive breast cancer?
Breast Cancer School for Patients Recommendations
Clinical Trials
Conclusion
What is HER2?
Brain metastases in HER2-positive Breast Cancer
New drugs in clinical trials for HER2-positive Breast Cancer
What are the side effects?
New HER2 inhibitors
New drug: unamilumab
What's new in research for brain metastases?
How many patients are in clinical trials?
What qualifies success in a trial?
How is HER2 tested?
Intro
What is HER2+ve cancer?
What does the HER2 protein do?
What does it mean if a breast cancer is HER2 positive?
How does your doctor know if your cancer is HER2 positive?
How is HER2 positive cancer treated?
What are the anti-HER2 drugs?
Monoclonal Antibodies
Herceptin
Perjeta
Phesgo
Who gets Herceptin, Perjeta and Phesgo?
Antibody Drug Conjugates
Kadcyla
Enhertu
Kinase Inhibitors
Tykerb
Tukysa
Nerlynx
Why you might not get Herceptin
What are the side effects of anti-HER2 treatment
HER2 low cancers and Enhertu
ASCO/CAP Guidelines for HER2 Classification by IHC
ASCO/CAP Guidelines for HER2 Classification by ISH
Current Binary Classification of HER2 in Breast Cancer
Prognostic Significance of HER2 Low
Mechanism of Action of HER2-Directed ADCs
DESTINY-Breast04: Safety Summary
HER2-low Is Unstable and Varies Over Time
Which Time Point Should You Use to Define HER2-Low Status in Patients With Breast Cancer?
How Low Can We Go? HER2 Zero, HER2 Low, and HER2 Ultralow
Patient Case: 56-Yr-Old Patient on T-DXd for 6 Mo and Suspected Asymptomatic ILD
Today's Agenda
Her2 Expression
Pre-Clinical Work
Curves for the Full Study Population
Lowest Threshold of Her2 Needed To Activate Tdxd
Subtypes
Is the Activity of Tdx Different According to Her to Expression
Take-Home Messages
Reproducibility among Pathologies
What Should Be the Minimum Threshold for Her to Expression Responding to the X