Opening Remarks

First reaction to receiving the award

Early life

Thyroid system

Thyroid hormone receptor is primarily localized in the nucleus

How does TR exit the nucleus?

Lysine to glutamine substitutions decrease nuclear localization

Nuclear import, export, and retention

Model of thyroid hormone receptor trafficking to the nucleus

What do we do to move forward?

Goal of Adjuvant Systemic Therapy

New Data in the Metastatic Setting

Progression Free Survival

Test if Someone Has Metastatic Breast Cancer

Pharmacological Therapy

While Taking Aromatase Inhibitors Is There any Effort To Decrease the Dosages or the Strength of these Medications from the Highest Tolerable Dose to the Lowest Effective Dose

How Do I Find Out What My Estrogen Receptor and Progesterone Receptor Percentage Positivity Are Where Do I

What Do You See on the Horizon for People Coping with Lobular Breast Cancer

Is It Possible for Progression To Skip to Other Organs Such as the Liver Lungs or Brain or Is It Is It Specific to the Patient or Is It Specific to Hormone Receptor Positive Status

How To Maintain Compliance by Managing Side Effects

How are hormone positive tumors treated?

Hormone therapy

Aromatase inhibitors

How can I reduce my risk of breast cancer?

Generalized structure of steroid hormone receptors

DNA binding domain

Hormone Response Elements

Generic steroid receptor structure

Hinge region

Type 1 vs Type 2

Why Study Receptor Pathways?

Steroid Hormones

Epinephrine

Cyclic AMP

Protein Kinase A (PKA)

G-Protein-Coupled Pathways

Diacylglycerol

Receptors for IP3

Heat Shock Proteins are Displaced

Recap

How steroid hormones work?

Types of steroid hormones

How steroid hormones trigger puberty?

What are intracellular receptors?

Structure of steroid hormone receptor

Ligand binding domain

Hormone response element

Estrogen receptor response element

Other intracellular receptors of steroid hormones

Summary

What are Breast Cancer Receptors?

What Are Receptors?

Estrogen Receptors

HER2 Receptors

Estrogen Receptor Positive Cancers

What Breast Cancer Receptors Suggest Hormonal Therapy?

Triple Negative Breast Cancer

What are the benefits of chemotherapy before surgery if my receptors suggest I need chemotherapy?

Chemotherapy

Breast Cancer School for Patients

Hormone-receptor interaction

Binding Site for Hormone

Steroid Receptors

Second Messengers

Cyclic AMP

Covalent Modification

Signals

Alteration of Gene Expression

Protein Kinase C

Cellular Signalling

Hormones and Growth

Hormones and healing

What do hormones do?

Lipid Bilayer

Hormones and Receptors

Lipid Bilayer Structure

Hormones as First Messengers

Types of Hormones

Progesterone

Conclusion

Peptide Hormones

Structure of Peptide Hormones

Target Cell Response to Hormone

Hormone Receptor

G-Protein Activation

Phospholipase C Activation

Second Messengers

Protein Kinase Activation

Cation Channels

Role of GPCRs in Drug Development

Treating Women with Hormone Receptor Positive Breast Cancer

Early Stage Breast

Oncotype Scores

Breast Cancer Index

Neoadjuvant Chemotherapy

Who Do You Recommend Adjuven Bisphosphonates for

Metastatic

Cytotoxic Chemotherapy

Estrogen Receptors

Estrogen

Fat Tissue

Receptors

Her2 Receptor

Egf Binding of the Her2

The Estrogen Receptor

Drugs

Tyrosine Kinase Inhibitor

Estrogen Transcription

Intro

How does cell communication take place?

Three Types of Signaling Pathways

Paracrine Signaling

Chemical Signals

Types of Signaling Molecules

Water Soluble Hormones

Glycogen Synthesis and Breakdown

Multiple Responses to Hormones

Conclusion