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Glucose metabolism in malignancy
Histone modifications are responsive to metabolic input
Epigenetic modification in response to excess glucose metabolism
The PI3K/AKT/TOR pathway reprograms glucose metabolism to fuel cell growth
IDH1 and IDH2 interconvert isocitrate and a-ketoglutarate.
Isocitrate dehydrogenase (IDH) mutations
IDH1/2 mutations occur exclusively in amino acids the render the proteins unable to bind isocitrate
A heterodimer between wildtype and mutant IDH1 potentiates 2HG production
What is mutant IDH doing in cancer?
IDH mutation inhibits hydroxylation of 5-methylcytosine by TET2.