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Introduction
Cell Cycle Regulation and Dysregulation
What are the key players in the CDK4/CDK6 pathway?
What is the history of CDK biology?
Mechanism of the CDK4/6-Cyclin D1-RB2F pathway
How is the cell cycle affected in breast cancer?
What is the role of cyclin D1 in breast cancer?
How do CDK4/6 inhibitors work?
What is the role of CDK4/6 inhibition in breast cancer?
Conclusion
What types of patients may best be treated in a trial?
What are the inclusion criteria for the PENELOPE-B trial?
What is the PRO trial?
MonaLisa-2 trial
Monarch II trial
Tips for identifying patients for clinical trials
Phase 1/2 trials of CDK4/6 inhibitors
What are the highlights to remember when referring patients to clinical trials?