How did you first get involved in the Human Genome Project?

Why was sequencing the whole human genome important?

What was your perspective on NIH directing the HGP?

Growing up in Brooklyn

Hampshire College Summer Studies in Mathematics

Serving on the Priorities Committee at Harvard

Mapping diseases relative to genetic markers

What is a gene and how does it relate to DNA?

Challenges

What's happened in the last decade?

The power of collaboration

Scientists have a responsibility to nurture the scientific process

Conclusion

Human Genome Project

How To Make Clinical Trials More Efficient

Assembling Teams

Not Afraid of Scale

Protein Folding

Programs of the Human Cell

James R. Killian,Jr. Faculty Achievement Award Lecture SECRETS of the HUMAN GENOME

Killian Lecture February 14, 2017

Mapping Disease Genes: Principles (1980-1990)

Mapping the Human Genome (1990-2003)

Mapping Disease Genes (2000-2006)

Mapping the Human Genome (2000-2006)

Mapping Disease Genes (2007-present)

Therapeutic hypothesis: Modulate synaptic pruning

How do you go from puzzling over pure math to deciphering the genetic code?

Winning the Westinghouse Science Talent Search

The genesis of genius

The Human Genome Project

Conclusion

Mobilizing the troops and testing everyone

What did we do differently?

Clear targets, regular check-ins to make decisions and solve problems

Achieving Under-24 Hour Turnaround Time

Manufacturing principles guide our work

Minimizing Turnaround Time

College and University Testing

Growing interest in the model

Even with vaccine on horizon, there is a need for increased testing

Acknowledgements

President Biden's Chief Science Advisor and Director of White House Office of Science and Technology Policy

Scientific Advisor to Federal Government

Ensure the Participation of all Americans

Public Trust

How Do We Compete with China and What Are the Concerns about the Security

Lessons Learned from Pandemic

Lessons from the Pandemic

Pandemic Preparedness

How Can Science and Innovation Help Us Address the Issue of Climate Change as Negative Consequences

Build Trust in Science

The relationship between the Whitehead Institute and MIT

Genome Center production floor

Accuracy of the sequence

Signal elements

Regulating protein translation

What makes vertebrate genes unique?

Applications of the Genome Project

The Human Genome Project and cancer studies

Future priorities for other species

Is the human genome a comprehensive description of life?

Human Genome Project

The Systematic Discovery of Disease Genes

The Basis of Simple Mendelian Traits

Common Diseases

Raising Hdl

Rare Genetic Variants

Understanding the Cancer Genome

Objections to the Project

Human Cancer Genome Project

Mutations Affecting Epigenomic Processes and Chromatin Regulation

Closing remarks

Intellectual change: Completeness

Most Conserved Non-Coding Elements

Three-dimensional architecture of the genome

Histone modifications

Do these chromatin domains encode functional non-coding RNAs?

What do non-coding RNAs do?

Localization of linked RNAs

Moving a transgene to a different part of the chromosome

RNA Story

Medical research at Uppsala University

Completion of the human genome

Genes that don't encode proteins

Regulatory evolution

Link RNA as a flexible scaffold for organizing protein complexes

Common genetic variants associated with common diseases

Cancer genome atlas

Big data can be incredibly powerful

What is the best way to lose weight?

Epigenetics