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Another hallmark of cancer is phenotypic plasticity. which is the ability of cells to change their type
Changes that manifest as epithelial-to-mesenchymal transition (EMT) states, and growing evidence suggests that NF-kB signaling is involved
Researchers have begun to uncover mechanistic links between NF-kB and the steps of EMT states
More research is needed to identify components of the NF-kB network involved in those mechanisms, but it may lead to new therapeutic targets
Overall, NF-kB and related factors show promise as therapeutic targets to reduce propensity of cancer cells to undergo EMT
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