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Intro
Fibrin or Fibrinogen Degradation Products
Primary Hyperfibrinolysis
Fibrin Before Factor 13
What is D-dimer?
Would a patient who has DIC show increased D-dimer?
Clinical Uses of D-Dimer
Can D-dimer rule out DVT?
High Pretest Probability Example
D-dimer has diagnostic, risk stratification, and prognostic value
Also known as Fragment D-dimer, or Cross-linked fibrin degradation product.
The D-Dimer is a by-product of the blood clotting and break-down process
One of the fibrin degradation products produced is D-dimer
An elevated D-dimer may be due to a Venous Thromboembolism
The test is used to help exclude a clot as the cause of symptoms.
D-dimer is recommended as an 'additional test!
It should not be the only test used to diagnose a disease or condition.
Both increased and normal D-dimer levels may require follow-up and can lead to further testing.