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Menin: A key checkpoint for beta cell homeostasis; an important target for type 1 and type 2 diabetes
Zucker Diabetic Fatty Rat -A model of insulin resistance
BMF-219 significantly reduces blood glucose, insulin, and c-peptide levels in ZDF Rats (After 2 Weeks of Dosing)
Streptozotocin (STZ) Rat, A type 2 diabetes model of beta cell loss
STZ Rat Model-Study Design
BMF-219 significantly reduced blood glucose by Oral Glucose Tolerance Test (OGTT) in an STZ-induced rat model
Human Donor Islets (Ex-Vivo): Statistically significant increase in beta cells with BMF-219