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When Wint is absent, the protein catenin is bound by a destruction complex which indudes protein kinases Cty and GSK-3B
The protein kinases phosphorylate ß-catenin, targeting it for ubiquitination and degradation in the proteasome
In absence of-caterin, transcriptional co-repressors bind to TCF transcription factors
1 The Wnt protein binds to the transmembrane receptor protein Frizzled
The protein kinases then phesphorylate the tail of the activated LRP
Next, the intracellular signaling protein Dishevelled and the protein Axin are recruited to the cytoplasmictails of LRP and Friend
This presents the formation of the destruction complex, meaning B-caterinaccumulates in the cytoplasm
Wnt1 gene
What happens in absence of Wnt?
Phosphorylation of β-catenin
Degradation of beta-catenin
Wnt activation
Dishevelled binds to Frizzled
Wnt-responsive genes
Role of Wnt signaling in cancer
Wnt signaling is important for formation and patterning of the hippocampus
Role of Wnt signaling in patterning of the brain
Wingless Spreading is Dispensable for Patterning of the Wing
Wnt Pathway Activity Peaks at Compartment Boundaries
The Midgut-Hindgut Boundary Epithelium
Wingless Expression at the Midgut-Hindgut Boundary
Gut Folding Near the Midgut-Hindgut Boundary
Wingless Spreading is Essential for Development of the Adult Gut